A general mechanism for network-dosage compensation in gene circuits.

Supporting Online Material for A General Mechanism for Network-Dosage Compensation in Gene Circuits

Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template

Natural and synthetic biological networks must function reliably in the face of fluctuating stoichiometry of their molecular components. These fluctuations are caused in part by changes in relative expression efficiency and the DNA template amount of the network-coding genes. Gene product levels could potentially be decoupled from these changes via built-in adaptation mechanisms, thereby boosti...

A Temperature Compensation Voltage Controlled Oscillator Using a Complementary to Absolute Temperature Voltage Reference

This paper presents a temperature compensation voltage controlled oscillator (VCO) based on Cross-Coupled pair and Colpitts structures which is suitable for military fields. Also, two inductors have been used for increasing the negative conductance. By using this method, start-up condition has been improved. Two varactors and a simple capacitor bank are applied for covering a wide tunning range...

DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome.

dpy-27 is an essential dosage compensation gene that acts to reduce expression of both hermaphrodite X chromosomes. The DPY-27 protein becomes specifically localized to the X chromosomes of wild-type XX embryos, but remains diffusely distributed throughout the nuclei of male (XO) embryos. In xol-1 mutant XO embryos that activate the XX mode of dosage compensation and die from inappropriately lo...

Noise reduction facilitated by dosage compensation in gene networks

Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network motif that is essential for network-dosage compensation can reduce the effect...